Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Triazines
  7. ML 228, Tocris Bioscience™

ML 228, Tocris Bioscience™

Catalog No. 456510
Click to view available options
Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

HIF pathway activator

HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM.

Chemical Identifiers

CAS 1357171-62-0
Molecular Formula C27H21N5
Molecular Weight (g/mol) 415.5
InChI Key QNRODODTMXCRKU-UHFFFAOYSA-N
Synonym n-1,1'-biphenyl-4-ylmethyl-6-phenyl-3-pyridin-2-yl-1,2,4-triazin-5-amine, ml228 probe, 6-phenyl-n-4-phenylphenyl methyl-3-2-pyridinyl-1,2,4-triazin-5-amine, n-1,1'biphenyl-4-ylmethyl-6-phenyl-3-2-pyridinyl-1,2,4-triazin-5-amine, n-biphenyl-4-ylmethyl-6-phenyl-3-pyridin-2-yl-1,2,4-triazin-5-amine
PubChem CID 46742353
IUPAC Name 6-phenyl-N-[(4-phenylphenyl)methyl]-3-pyridin-2-yl-1,2,4-triazin-5-amine
SMILES C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=C(N=NC(=N3)C4=CC=CC=N4)C5=CC=CC=C5

Specifications

Quantity 10 mg
Formula Weight 415.49
Percent Purity >98%
Chemical Name or Material ML 228

Safety and Handling

Recommended Storage Store at -20°C
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.