Tocris ML 347
Potent and selective ALK1 and ALK2 inhibitor
Manufacturer: Tocris 4945/10
DescriptionPotent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152nM).
- Chemical Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
- Formula: C22H16N4O
- CAS Number: 1062368-49-3
- Solubility: Soluble to 20mM in DMSO
- Purity: >98
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