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  5. Tocris Bioscience™ ML 351

Tocris Bioscience™ ML 351

Catalog No. 64485
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective 12/15 LOX inhibitor; active in vivo

ML 351 is a selective 12/15 LOX inhibitor (IC50 = 200 nM). Exhibits >250-fold selectivity over related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. Protects against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and reduces infarct size in a mouse ischemic stroke model.

Specifications

Chemical Name or Material 5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile
CAS 847163-28-4
Quantity 5 mg
Molecular Formula C15H11N3O
Purity 98%
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