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Invitrogen™ MLK4 Polyclonal Antibody
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Catalog No. PIPA599276
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100 μL
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PIPA599276 100 μL
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Catalog No. PIPA599276 Supplier Invitrogen™ Supplier No. PA599276
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MLK4.

MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas. MLK4 is a negative regulator of TLR4 and does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MLK4
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MAP3K21
Gene Accession No. Q5TCX8
Gene Alias BC021891; cDNA sequence BC021891; dJ862P8.3; Kiaa1804; MAP3K21; Mitogen-activated protein kinase kinase kinase 21; Mitogen-activated protein kinase kinase kinase MLK4; mixed lineage kinase 4; mKIAA1804; MLK4; RGD1306091; similar to Mixed lineage kinase 4
Gene Symbols MAP3K21
Host Species Rabbit
Immunogen A synthesized peptide derived from human MAP3K21(Accession Q5TCX8), corresponding to amino acid residues S862-A912.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84451
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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