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MLN51/CASC3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
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Catalog No. 501731958 Shop All Proteintech Group Inc Products
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50-173-1958 150 μL
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Catalog No. 50-173-1958 Supplier Proteintech Group Inc Supplier No. 180471AP150UL
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Description

Rabbit Polyclonal Antibody

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified.

Specifications

Antigen MLN51/CASC3
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Concentration 0.33 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CASC3
Gene Accession No. O15234, Q8K3W3, Q8K3X0
Gene Alias BTZ, CASC3, MLN 51, MLN51, Protein barentsz, Protein CASC3
Gene Symbols Casc3
Host Species Rabbit
Immunogen MLN51/CASC3 Fusion Protein Ag12694
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 192160, 22794, 259170
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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