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Invitrogen™ MMAF Monoclonal Antibody (A5G11)
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Catalog No. PIMA542538
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100 μL
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PIMA542538 100 μL
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Catalog No. PIMA542538 Supplier Invitrogen™ Supplier No. MA542538
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Description

Mouse Monoclonal Antibody

Product has been tested in direct ELISA.

Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of the approved drug belantamab mafodotin in multiple myeloma and some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody. Monomethyl auristatin F is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells. MMAF is actually desmethyl-auristatin F; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin F itself.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MMAF
Applications ELISA
Classification Monoclonal
Clone A5G11
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene Alias Monomethyl auristatin F
Host Species Mouse
Immunogen MMAF coupled with OVA.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
Target Molecule Chemical
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