Invitrogen™ MMAF Monoclonal Antibody (A5G12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA542537

Catalog No. PIMA542537

Description

Product has been tested in direct ELISA.

Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of the approved drug belantamab mafodotin in multiple myeloma and some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody. Monomethyl auristatin F is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells. MMAF is actually desmethyl-auristatin F; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin F itself.

Specifications

• Antigen: MMAF
• Classification: Monoclonal
• Concentration: 2 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Target Species: Chemical
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA
• Clone: A5G12
• Conjugate: Unconjugated
• Gene Alias: Monomethyl auristatin F
• Immunogen: MMAF coupled with OVA.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid
• Target Molecule: Chemical