MMP13 Mouse anti-Human, Clone: OTI1G5, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF506689

Catalog No. 50-166-4400

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.

Specifications

• Antigen: MMP13
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: MMP13
• Gene Alias: CLG3, MANDP1, MDST, MMP-13
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4322
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1G5
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P45452
• Gene Symbols: MMP13
• Immunogen: Human recombit protein fragment corresponding to amino acids 104-471 of human MMP13 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a