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Invitrogen™ MMP14 Polyclonal Antibody
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PIPA513183 400 μL
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Catalog No. PIPA513183 Supplier Invitrogen™ Supplier No. PA513183
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with bovine, mouse, porcine and rat based on sequence homology.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MMP14
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene MMP14
Gene Accession No. P50281, P53690, Q10739
Gene Alias AI325305; cb386; EC 3.4.24.80; matrix metallo protease; matrix metallopeptidase 14; matrix metallopeptidase 14 (membrane-inserted); matrix metallopeptidase 14a (membrane-inserted); matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase 14 (membrane-inserted) alpha; matrix metalloproteinase 14 membrane-inserted; matrix metalloproteinase 14, membrane-inserted; matrix metalloproteinase 14a (membrane-inserted); matrix metalloproteinase-14; matrix metalloproteinase-14a; membrane type 1 metalloprotease; membrane type 1-matrix metalloproteinase; Membrane type 1-MMP; membrane-type matrix metalloproteinase 1; membrane-type matrix metalloproteinase 1 alpha; membrane-type-1 matrix metalloproteinase; MMP; MMP14; MMP-14; mmp14a; MMPs; MMP-X MT-MMP; MMP-X1; MT1MMP; MT1-MMP; MT1-MMP-alpha; Mtmmp; MT-MMP; MT-MMP 1; MT-MMP MT1-MMP; MTMMP1; MT-MMP-1; MT-MMPalpha; sabe; sb:cb386; type 1 matrix metalloprotease 14; WNCHRS; wu:fb72b09; zMT-MMPalpha; zMT-MMP-alpha
Gene Symbols MMP14
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 145-174 amino acids from the N-terminal region of human MMP14.
Purification Method Protein A, Antigen affinity chromatography
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17387, 4323, 81707
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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