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Apexbio Technology LLC NCT-501 1802088-50-1 5mg
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Supplier:  Apexbio Technology LLC B60445

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NCT-501 (CAS 1802088-50-1) is a theophylline-derived potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1) ALDH1A1 plays a significant role in the metabolism of endogenous and exogenous aldehydes and is implicated in cancer biology particularly as a prognostic marker in prostate cancer and in cancer stem cell maintenance NCT-501 inhibits ALDH1A1 reversibly and has demonstrated inhibition of over 55% activity in a panel of more than 450 human kinases at 10 M In vivo intraperitoneal administration at 30 mg/kg yields higher plasma exposure and bioavailability compared to oral dosing NCT-501 serves as a valuable tool for investigating ALDH1A1 function and for studying aldehyde dehydrogenase involvement in cancer and metabolic disorders

Catalog No. 50-000-90171


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