Invitrogen CM-H2DCFDA (General Oxidative Stress Indicator)
General oxidative stress indicator
Manufacturer: Invitrogen C6827
CM-H2DCFDA is chloromethyl derivative of H2DCFDA useful as indicator for reactive oxygen species (ROS) in cells. This indicator exhibits much better retention in live cells than H2DCFDA. CM-H2DCFDA passively diffuses into cells, where its acetate groups are cleaved by intracellular esterases and its thiol-reactive chloromethyl group reacts with intracellular glutathione and other thiols. Subsequent oxidation yields a fluorescent adduct that is trapped inside the cell, thus facilitating long-term studies.
- Ex/Em: approx. 492 - 495/517527nm
- Product is air sensitive (store under dry argon or nitrogen)
- Product may be dissolved in DMSO, DMF, or ethanol for use
- Indicator is cell permeant
- Fluorescence can be monitored using a flow cytometer, fluorometer, microplate reader, or fluorescence microscope, using excitation sources and filters appropriate for fluorescein
Refer to the Molecular Probes Handbook for additional product information.
Apoptosis, Cell Analysis, Cell Metabolism, Cell Viability, Proliferation and Function, Free Radical Detection, Nitro-Oxidative Stress, Reactive Oxygen Species
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Shipping Condition: Room Temperature
|Store in freezer (-5 to -30°C).|
|Free Radical Sensor|
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For Research Use Only. Not for use in diagnostic procedures.