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MilliporeSigma™ Mouse anti-acetyl-alpha tubulin, Clone: 6-11B-1,

Catalog No. MABT868MI Shop All MilliporeSigma Products
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Description

Mouse Monoclonal Antibody

Specifically detects acetyl-alpha tubulin clone: 6-11B-1 in Bovine, Drosophila, Human, Monkey, Mouse, Sea Urchin samples, and it is validated for Dot Blot, Electron Microscopy

Microtubules are cytoskeletal filaments composed of of alpha-/beta-tubulin heterodimers that self-assemble head-to-tail to form protofilaments and laterally to form a hollow tube. Various post-translational modifications (PTMs), including acetylation, polyglutamylation, polyglycylation, detyrosination, phosphorylation, and palmitoylation, can regulate the polymerization properties of tubulins and/or their interactions with microtubule associated proteins (MAPs) and motor proteins. A subset of cytoplasmic microtubules and microtubules in the spindle, axon, and cilia are known to contain alpha-tubulin acetylated via the epsilon-amino group of Lysine-40 (K40). The GNAT lysine acetyltransferase family member MEC-17 (or alpha-tubulin acetyltransferase/alphaTAT) catalyzes K40 acetylation, while HDAC6 and sirtuin2 (SIRT2) are known to catalyze tubulin deacetylation. Experimental evidences indicate that K40 acetylation primes alpha-tubulin for further PTM(s), which cannot be reversed by later deactylation of K40ac. Subsequently, the acetylated and deacetylated alpha-tubulin in native microtubules are structurally distinct from that of unacetylated alpha-tubulin (never before has its K40 acetylated).
TRUSTED_SUSTAINABILITY

Specifications

Antigen acetyl-alpha tubulin
Applications Dot Blot, Immunoassay
Classification Monoclonal
Clone 6-11B-1
Formulation Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P18258
Gene Symbols acetyl-alpha tubulin
Host Species Mouse
Immunogen 15 S dynein fraction from sea urchin sperm axoneme.
Purification Method Protein G Purified
Quantity 200 μg
Regulatory Status RUO
Research Discipline Cell Structure
Primary or Secondary Primary
Gene ID (Entrez) AEI99579.1
Target Species Bovine, Drosophila, Human, Monkey, Mouse, Sea urchin
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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For Research Use Only

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