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Description
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, nonsmall cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq
Specifications
Specifications
| Antigen | BRAF |
| Applications | ELISA, Immunohistochemistry, Western Blot |
| Classification | Monoclonal |
| Clone | 1F12F11C9, 1H12F1, 1H12G10 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against recombinant BRAF. |
| Dilution | Western Blot (1:500-1:2000) Immunohistochemistry (1:200-1:1000) ELISA (1:10000) The optimal working dilution should be determined by the end user. |
| Formulation | In ascitic (0.03% sodium azide) |
| Gene | BRAF |
| Gene Alias | B-RAF1/BRAF1/FLJ95109/MGC126806/MGC138284/RAFB1 |
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