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CD3 Mouse anti-Human, APC-R700, Clone: UCHT1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 565120

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Catalog No. BDB565120


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Description

Description

The UCHT1 monoclonal antibody specifically binds to the human CD3 ε -chain, a 20-kDa subunit of the CD3/T cell antigen receptor complex. CD3 ε is expressed on 70-80% of normal human peripheral blood lymphocytes and 60-85% of thymocytes. Studies from the HLDA Workshop show that this antibody is mitogenic for CD3 ε -positive cells when used in conjunction with costimulatory agents such as pokeweed mitogen or anti-CD28 antibody. CD3 plays a central role in signal transduction during antigen recognition. The UCHT1 antibody stains both surface and intracellular CD3 ε unlike the other CD3 clone, HIT3a, that stains only extracellular CD3 ε .

This antibody was conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700. APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness. This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45-nm filter).

Specifications

Specifications

CD3
UCHT1
CD3e; CD3E; T3E; TCRE; T-cell surface antigen T3/Leu-4 epsilon
Affinity Purified
Human infant thymocytes and peripheral blood lymphocytes from a Sezary Syndrome donor
Affinity Chromatography
RUO
Primary
Human
Flow Cytometry
APC-R700
Aqueous buffered solution containing BSA, protein stabilizer, glycerol, and ≤0.09% sodium azide.
Murine
IgG1, κ
25 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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