MilliporeSigma™ Mouse anti-CEACAM8, Clone: 6/40c,

Catalog No.	Quantity
MABT324MI	100 μg

Catalog No. MABT324MI Supplier MilliporeSigma™ Supplier No. MABT324

Description

Mouse Monoclonal Antibody

Specifically detects CEACAM8 clone: 6/40c in Human samples, and it is validated for ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting

The carcinoembryonic antigen- (CEA-) related cell adhesion molecules (CEACAMs) constitute a 12-member subgroup of the CEA family of immunoglobulin-related proteins first described in 1965 (PMID 4953873). CEACAMs are reported to participate in diverse physiological processes, including cell adhesion, differentiation, proliferation, and survival, as well as in carcinogenesis and bacterial pathogenesis. CEACAM molecules from neighbouring cells can interact via their respective extracellular N-terminal IgV-like domain and mediate cell-cell adhesion through trans-oligomerization. CEACAM molecules within the same cell can also undergo transmembrane domain-mediated cis-oligomerization, an event important for sustaining downstream cellular signaling. Athough CEACAM1 is shown to utilize its cytoplasmic domain for transducing cellular signaling, not all CEACAM members are expressed with a significant cytoplasmic domain, and others (CEACAM5/6/7/8) are GPI-anchored without even a transmembrane domain. (PMID 4735478). Human CEACAM8 (also known as CEA gene family member 6, CEA-related cell adhesion molecule 8, CD66b, CD67 antigen, Non-specific crossreacting antigen NCA-95; UniProt P31997 and Q0Z7S6) is encoded by the CEACAM8 (or CGM6) gene (NCBI Gene ID 1088). It is a GPI-anchored CEACAM with three extracellular Ig domains. Clone 6/40c does not cross-react with human CEACAM1/3/4/5/6/7, rat CECAM1, or mouse CEACAM1/2.

Specifications

• Antigen: CEACAM8
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: 6/40c
• Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: P31997
• Gene Symbols: CEACAM8; CGM6
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to the extracellular domain of human CEACAM8.
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Cell Structure
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001807
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG1 κ

For Research Use Only