MilliporeSigma™ Mouse anti-CEACAM8, Clone: 6/40c,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABT324

Catalog No. MABT324MI

Description

Specifically detects CEACAM8 clone: 6/40c in Human samples, and it is validated for ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting

The carcinoembryonic antigen- (CEA-) related cell adhesion molecules (CEACAMs) constitute a 12-member subgroup of the CEA family of immunoglobulin-related proteins first described in 1965 (PMID 4953873). CEACAMs are reported to participate in diverse physiological processes, including cell adhesion, differentiation, proliferation, and survival, as well as in carcinogenesis and bacterial pathogenesis. CEACAM molecules from neighbouring cells can interact via their respective extracellular N-terminal IgV-like domain and mediate cell-cell adhesion through trans-oligomerization. CEACAM molecules within the same cell can also undergo transmembrane domain-mediated cis-oligomerization, an event important for sustaining downstream cellular signaling. Athough CEACAM1 is shown to utilize its cytoplasmic domain for transducing cellular signaling, not all CEACAM members are expressed with a significant cytoplasmic domain, and others (CEACAM5/6/7/8) are GPI-anchored without even a transmembrane domain. (PMID 4735478). Human CEACAM8 (also known as CEA gene family member 6, CEA-related cell adhesion molecule 8, CD66b, CD67 antigen, Non-specific crossreacting antigen NCA-95; UniProt P31997 and Q0Z7S6) is encoded by the CEACAM8 (or CGM6) gene (NCBI Gene ID 1088). It is a GPI-anchored CEACAM with three extracellular Ig domains. Clone 6/40c does not cross-react with human CEACAM1/3/4/5/6/7, rat CECAM1, or mouse CEACAM1/2.

Specifications

• Antigen: CEACAM8
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: CEACAM8; CGM6
• Immunogen: Recombinant protein corresponding to the extracellular domain of human CEACAM8.
• Quantity: 100 μg
• Research Discipline: Cell Structure
• Gene ID (Entrez): NP_001807
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG1 κ

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 6/40c
• Gene Accession No.: P31997
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only