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MilliporeSigma™ Mouse anti-HOIL-1, Clone: 2E2,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABC576

Catalog No. MABC576MI


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Description

Description

Specifically detects HOIL-1 clone: 2E2 in Human, Mouse samples, and it is validated for Immunocytochemistry, Western Blotting

RanBP-type and C3HC4-type zinc finger-containing protein 1 (UniProt Q9BYM8; also known as HOIL-1, HBV-associated factor 4, Heme-oxidized IRP2 ubiquitin ligase 1, Hepatitis B virus X-associated protein 4, RBCC protein interacting with PKC1, RING finger protein 54, Ubiquitin-conjugating enzyme 7-interacting protein 3) is encoded by the RBCK1 gene (also known as C20orf18, HOIL1, PBMEI, RBCK2, RNF54, UBCE7IP3, XAP3, XAP4, ZRANB4) (Gene ID 10616) in human. The linear ubiquitin assembly complex (LUBAC) is comprised of two RING-IBR-RING (RBR)-containing E3 ligases, HOIL-1L and HOIP. LUBAC conjugates a head-to-tail-linked linear polyubiquitin chain onto lysine residues on substrate proteins. Ovarian tumor deubiquitinating enzyme (DUB) with linear linkage specificity (OTULIN/Gumby/FAM105B) and cylindromatosis (CYLD) are two DUBs that catalyze the cleavage linear polyubiquitin chains. OTULIN and CYLD interact with the N-terminal PNGase/UBA or UBX (PUB) domain of HOIP and negatively regulate LUBAC-mediated cellular processes. LUBAC is reported to suppress IFN-dependent antiviral activity by mediating TRIM25 degradation and competing against TRIM25 for RIG-I interaction.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

HOIL-1
Monoclonal
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
RBCK1; C20orf18; RNF54; UBCE7IP3; XAP3; XAP4
GST-tagged recombinant protein corresponding to human HOIL-1 near the C-terminus.
100 μg
Apoptosis, Cancer
NP_006453
Stable for one year at 2°C to 8°C from date of receipt.
IgG1 κ
Immunocytochemistry, Western Blot
2E2
Q9BYM8
Mouse
Protein G Purified
RUO
Primary
Human, Mouse
Purified
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