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Description
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq
Specifications
Specifications
| Antigen | IGF1R |
| Applications | ELISA, Immunohistochemistry, Western Blot |
| Classification | Monoclonal |
| Clone | 3G5C1 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against partial recombinant IGF1R. |
| Dilution | ELISA (1:10000) Western Blot (1:500-1:2000) Immunohistochemistry (1:200-1:1000) The optimal working dilution should be determined by the end user. |
| Formulation | In ascites (0.03% sodium azide) |
| Gene | IGF1R |
| Gene Alias | CD221/IGFIR/JTK13/MGC142170/MGC142172/MGC18216 |
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