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Insulin Mouse, Alexa Fluor 647, Clone: T56-706, BD

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BDB565689 25 μg
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Catalog No. BDB565689 Supplier BD Biosciences Supplier No. 565689
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Description

Mouse Monoclonal Antibody

The T56-706 monoclonal antibody specifically binds to insulin, a member of the insulin family of active peptides. Insulin is an evolutionarily conserved peptide hormone that binds to receptors on target cells (primarily adipose and muscle) to promote the absorption of glucose from the blood, thus regulating fat and carbohydrate metabolism. Insulin is produced by β cells in the islets of Langerhans of the pancreas. There, the precursor molecule, preproinsulin, is cleaved to proinsulin that is in turn cleaved to form the mature insulin hormone, which is composed of two peptides (A- and B-chains) linked by 2 disulfide bonds. Mature insulin is stored in granules in the β cells and is released to the blood in response to metabolic signals such as glucose, the amino acids arginine and leucine, and acetylcholine. Catecholamines can regulate blood glucose levels by either stimulating or inhibiting the release of insulin from β cells . The expression of insulin can be used to monitor the pancreatic differentiation of pluripotent stem cells.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Insulin
Applications Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunocytochemistry
Classification Monoclonal
Clone T56-706
Concentration 0.2mg/mL
Conjugate Alexa Fluor 647
Description INS; IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10; Ins2
Formulation Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mature human insulin (A- and B-chain) Recombinant Protein
Purification Method Affinity Purified
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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