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MilliporeSigma™ Mouse anti-Kallikrein-1/KLK1, Clone: 11C7.1,

Catalog No. MABC552MI Shop All MilliporeSigma Products
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MABC552MI 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects Kallikrein-1/KLK1 clone: 11C7.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Kallikrein-1 (EC:3.4.21.35; UniProt P06870; also known as Glandular kallikrein 1, hK1, Kallikrein serine protease 1, Kidney/pancreas/salivary gland kallikrein, Renal/pancreas/salivary kallikrein 1, Tissue kallikrein) is encoded by the KLK1 (also known as KLKR) gene (Gene ID 3816) in human. Kallikrein-1 is a member of the kallikrein subfamily of serine proteases, members of which are involved in diverse physiological functions and many are used clinically as biomarkers for cancer. Kallikrein-1 is initially produced as a preproprotein with a signal (aa 1-18) and a propeptide (aa 19-24), cleavage of which releases the mature protein (aa 25-262). Kallikrein-1 is the major kallikrein expressed in the kidney, where it generates kinins (e.g. lysyl-bradykinin and bradykinin) and plays role in kidney function and blood pressure regulation through vasodilatory and natriuretic effects. Decreased kidney Kallikrein-1 level is reported in experimental settings of hypertension, diabetic nephropathy, high salt- and aminoglycoside-induced kidney injury.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kallikrein-1/KLK1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 11C7.1
Formulation Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P06870
Gene Symbols KLK1
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to the C-terminal half of human Kallikrein-1/KLK1.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Apoptosis, Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_002248
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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