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MilliporeSigma™ Mouse anti-Neurophysin 1, Clone: PS 38,

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MABN844MI 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects Neurophysin 1 clone: PS 38 in Rat samples, and it is validated for Western Blotting

Neurophysins are linear cycteine-rich proteins containing 93-95 amino acids. Two types of neurophysins, NPI and NPII are found in most mammalian species and they serve as carriers of oxytocin (OT) and vasopressin (AVP), respectively. Each NP and its associated hormone is synthesized as one precursor protein, OT-NPI (UniProt P01179) encoded by the Oxt (or Ot) gene or VAP-NPII (UniProt P01186) encoded by the Avp gene in rat species. Post-translational cleavages remove the signal peptide and process the precursor into mature OT and NPI (aa 20-28 and aa 32-135, respectively, of OT-NPI), or AVP and NPII (aa 24-32 and aa 36-128, respectively, of AVP-NPII). OT is a potent hormone and neurotransmitter secreted within the pituitary gland. OT exerts its biological activity through its receptor OXTR (also known as OTR). OT is used clinically for labor induction and may exhibit therapeutic potential for treating social anxiety disorders. VAP functions primarily as an anti-diuretic and regulates the concentration of water, glucose, and salts in blood. VAP is secreted from the posterior pituitary, but exerts its biological activity in the kidney via the G protein-coupled receptor AVPR2 (V2R).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Neurophysin 1
Applications Western Blot
Classification Monoclonal
Clone PS 38
Formulation Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P01179
Gene Symbols Oxt; Ot
Host Species Mouse
Immunogen KLH-conjugated acid soluble extract of rat (Sprague-Dawley) intermediate lobes corresponding to rat Neurophysin 1.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_037128
Target Species Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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