MilliporeSigma™ Mouse anti-Ninjurin-1/NINJ1, Clone: 12H6.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABN816

Catalog No. MABN816

Description

Specifically detects Ninjurin-1/NINJ1 clone: 12H6.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Ninjurin-1 (UniProt Q92982; also known as Nerve injury-induced protein 1) is encoded by the NINJ1 (also known as NIN1, NINJURIN) gene (Gene ID 4814) in human. Ninjurin-1 (NINJ1) is a cell surface adhesion molecule originally identified to be up-regulated in neuronal and Schwann cells after sciatic nerve injury. NINJ1 is also reported to play a role in the progression of multiple sclerosis, an autoimmune inflammatory CNS disease characterized by demyelination and axonal damage. In addition, NINJ1 is known to cause regression of hyaloid blood vessels important for the maturation of the lens during embryonic development. Consistent with the latter role in vascular system, Penile injection of Ninj1-neutralizing antibody is shown to significantly restore erectile function in a murine model of diabetic erectile disfunction (ED) as a result of enhanced cavernous endothelial cell proliferation. Human Ninjurin-1 is a 152-amino aicd protein with boht its N- and C-terminal ends exposed extracellulary (a.a. 1-80, 142-152) and a short intracellular segment (a.a. 102-119) sandwiched between two transmembrane domains (a.a. 81-101, 121-141).

Specifications

• Antigen: Ninjurin-1/NINJ1
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: NINJ1; NIN1; NINJURIN
• Immunogen: GST-tagged recombinant human Ninjurin-1/NINJ1 N-terminal extracellular domain.
• Quantity: 100 μg
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_004139
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG1 κ

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 12H6.1
• Gene Accession No.: Q92982
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only