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  6. Mouse anti-p73α/Β Monoclonal Antibody, Clone: ER-13 + ER-15 + GC-15, Epredia™ LabVision

Mouse anti-p73α/Β Monoclonal Antibody, Clone: ER-13 + ER-15 + GC-15, Epredia™ LabVision

Catalog No. p-3034508 Shop All Epredia Products
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Quantity:
100 μL
200 μL
500 μL
1 mL
Concentration:
1mg/mL
200μg/mL
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Catalog No. Quantity Concentration
MS764P0 100 μL 200μg/mL
MS764P1 500 μL 200μg/mL
MS764P 1 mL 200μg/mL
MS764P1ABX 100 μL 1mg/mL
MS764PABX 200 μL 1mg/mL
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Catalog No. MS764P0 Supplier Epredia Supplier No. MS764P0

Description

Mouse Monoclonal Antibody

p73 exhibits sequence homology to the p53's transcriptional activation, DNA binding, and oligomerization domains. However, adenovirus E1B 55K, simian virus 40 T, and human papillomavirus E6 do not physically interact with p73 indicating that the functions of these two proteins may differ under physiological conditions. p73 is expressed in either a full-length form (α) (MW ∽80kDa) or a shorter (Β) (MW ∽70kDa) mRNA variant, with exon 13 spliced out. Transient overexpression of p73 in cells can induce apoptosis and p21, a cellular p53 target gene primarily responsible for p53-dependent cell cycle arrest.

Host Species: Mouse
Clone: ER-13 + ER-15 + GC-15
Isotype: IgG1 + IgG1 + IgG1
Species Reactivity: Human and Monkey. Others not known.
Epitope: aa 380-637
Immunogen: Purified monkey recombinant p73α protein (aa 380-637, clones ER-13 and ER-15); Purified monkey recombinant p73β protein (aa 380-499, clone GC-15)
Molecular Weight: 80kDa (p73α) and 70kDa (p73β)
Positive Control: COS monkey kidney cells and IM9 human myeloma cells; SK-N-AS human neuroblastoma cells lack p73α/β
Cellular Localization: Nuclear

Ab-4 is especially designed for a sensitive detection of both p73α and p73β in immunoprecipitation and Western Blot assays.

USA: RUO; Int'l: RUO

Western Blotting, Immunofluorescence, Immunoprecipitation, Gel Supershift

Specifications

Antigen p73α/β Ab-4
Classification Monoclonal
Clone ER-13 + ER-15 + GC-15
Concentration 200μg/mL
Conjugate BSA
Host Species Mouse
Immunogen Purified monkey recombinant p73α protein (aa380-637) (clones ER-13 and ER-15); Purified monkey recombinant p73Β protein (aa380-499) (clone GC-15)
Quantity 100 μL
Primary or Secondary Primary
Target Species Human, Monkey
Form Purified
Isotype IgG1
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