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MilliporeSigma™ Mouse anti-PERK, Clone: 4F6.1,

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MABN842MI 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects PERK clone: 4F6.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1; UniProt Q9NZJ5; also known as Eukaryotic translation initiation factor 2 alpha kinase 3, HsPEK, Pancreatic EIF2-alpha kinase, PRKR-like endoplasmic reticulum kinase) is encoded by the EIF2AK3 (also known as PEK, PERK, WRS) gene (Gene ID 9451) in human. The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) induces the activation of three main unfold protein response (UPR) pathways, the inositol requiring enzyme-1 (IRE1) pathway, the activating transcription factor 6 (ATF6) pathway, and the protein kinase-like ER kinase (PERK) pathway. The PERK pathway involves PERK auto-phosphorylation/activation, resulting in PERK phosphorylation of eIF2α, which in turn leads to increased ATF4 transcription and ATF4-mediated CAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) upregulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PERK
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 4F6.1
Formulation Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. Q9NZJ5
Gene Symbols EIF2AK3; PEK; PERK
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to the Internal (C-terminal half) of human PERK.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_004827
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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