MilliporeSigma Mouse anti-PP2A, C subunit, Clone: 1D6, Alexa Fluor 488,
Mouse Monoclonal Antibody
Manufacturer: MilliporeSigma 05421AF488
Specifically detects PP2A, C subunit clone: 1D6 in Bovine, Human, Mouse, Rabbit, Rat, Xenopus, Yeast samples, and it is validated for ImmunocytochemistrySerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (EC 126.96.36.199; UniProt P67775; PP2A-alpha, PP2Ac, PP2Calpha, Replication protein C, RP-C) is encoded by the PPP2CA (also known as PP2CA) gene (Gene ID 5515) in human. Protein phosphatase 2 (PP2 or PP2A) is a ubiquitously expressed heterotrimeric serine/threonine protein phosphatase with broad substrate specificity, such as Raf, MEK, and AKT. PP2A is composed of a structural A and a catalytic C subunit as the dimeric core enzyme, and a regulatory B subunit. There exist two different A subunits (PPP2R1A & PPP2R1B), two different C subunits (PPP2CA & PPP2CB), and 12 different B subunits (PPP2R2B-D, PPP2R3A-C, PPP2R4, PPP2R5A-E). The enzymatic activity of a catalytic subunit is altered upon binding an A subunit even in the absence of a B subunit. The B subunits are believed to play key roles in controlling the localization and specific activity of the A/C holoenzymes.
|PP2A, C subunit|
|Purified mouse monoclonal IgG2bκ antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.|
|Alexa Fluor 488|
|A 16 residue synthetic peptide (C-RGEPHVTRRTPDYFL) corresponding to amino acids 295-309 of the 36kDa catalytic subunit of human protein phosphatase 2A (PP2A).|
|Protein A Purfied|
|Stable for one year at 2°C to 8°C from date of receipt.|
|Bovine, Human, Murine, Rabbit, Rat, Xenopus, Yeast|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
For Research Use Only