MilliporeSigma™ Mouse anti-PP2A, C subunit, Clone: 1D6, Alexa Fluor 488,

Mouse Monoclonal Antibody

Manufacturer:  MilliporeSigma™ 05421AF488

Catalog No. 05-421-AF488

Description

Specifically detects PP2A, C subunit clone: 1D6 in Bovine, Human, Mouse, Rabbit, Rat, Xenopus, Yeast samples, and it is validated for Immunocytochemistry

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (EC 3.1.3.16; UniProt P67775; PP2A-alpha, PP2Ac, PP2Calpha, Replication protein C, RP-C) is encoded by the PPP2CA (also known as PP2CA) gene (Gene ID 5515) in human. Protein phosphatase 2 (PP2 or PP2A) is a ubiquitously expressed heterotrimeric serine/threonine protein phosphatase with broad substrate specificity, such as Raf, MEK, and AKT. PP2A is composed of a structural A and a catalytic C subunit as the dimeric core enzyme, and a regulatory B subunit. There exist two different A subunits (PPP2R1A & PPP2R1B), two different C subunits (PPP2CA & PPP2CB), and 12 different B subunits (PPP2R2B-D, PPP2R3A-C, PPP2R4, PPP2R5A-E). The enzymatic activity of a catalytic subunit is altered upon binding an A subunit even in the absence of a B subunit. The B subunits are believed to play key roles in controlling the localization and specific activity of the A/C holoenzymes.

Specifications

• Antigen: PP2A, C subunit
• Clone: 1D6
• Formulation: Purified mouse monoclonal IgG2bκ antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
• Format: Purified
• Host Species: Murine
• Isotype: IgG2b, κ
• Quantity: 100μL
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_002706

• Applications: Immunocytochemistry
• Conjugate: Alexa Fluor 488
• Gene Accession No.: P67775
• Gene Symbols: PPP2CA; PP2CA
• Immunogen: A 16 residue synthetic peptide (C-RGEPHVTRRTPDYFL) corresponding to amino acids 295-309 of the 36kDa catalytic subunit of human protein phosphatase 2A (PP2A).
• Purification Method: Protein A Purfied
• Regulatory Status: RUO
• Storage Requirements: Stable for one year at 2°C to 8°C from date of receipt.
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Bovine, Human, Murine, Rabbit, Rat, Xenopus, Yeast

For Research Use Only