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MilliporeSigma™ Mouse anti-α-syn (aa 115-122), Clone: LB509,

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MABN824MI 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects α-syn (aa 115-122) clone: LB509 in Human samples, and it is validated for Immunohistochemistry, Western Blotting

alpha-Synuclein is a small (140 amino acid) cytoplasmic protein of unclear function that is enriched in presynaptic terminals and is the precursor protein of a nonamyloid beta component of senile plaques in Alzeheimer's Disease (AD). α-Synuclein is located predominantly in the presynaptic nerve terminals in the brain but is also found in low concentrations in all tissues except liver. Studies have shown that abnormal aggregation and accumulation of synaptic proteins, including α-Synuclein, might be associated with plaque formation in AD and a major component of Lewy bodies in dementia with Lewy bodies (DLB). It has also been identified in the Glial Cytoplasmic Inclusions (GCIs) found in Multiple System Atrophy (MSA). Clone LB509 detects epitope in the region from amino acid 115 to 122 and has been used to characterize the digestion patterns of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).
TRUSTED_SUSTAINABILITY

Specifications

Antigen α-syn (aa 115-122)
Applications Immunohistochemistry, Western Blot
Classification Monoclonal
Clone LB509
Formulation Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P37840
Gene Symbols SNCA; NACP; PARK1
Host Species Mouse
Immunogen Conjugated linear peptide corresponding to human α-syn (aa 115-122).
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_000336
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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