Gibco™ Mouse Artemin Recombinant Protein, PeproTech®

Description

Recombinant Protein

Recombinant Murine Artemin is a disulfide-linked homodimer formed by two identical 113 amino acid subunits with a calculated molecular weight of 24.2 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Accession Number: Q9Z0L2
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 11876
• Molecular Weight (g/mol): 12.1 kDa
• Name: Mouse Artemin
• Quantity: 1 mg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: Artemin; ARTN; Enovin; EVN; NBN; neublastin; neurotrophic factor
• Common Name: Artemin
• Gene Symbol: ARTN
• Biological Activity: Determined by the dose-dependent stimulation of the proliferation of SH-SY5Y cells. The expected ED50 for this effect is 0.1-0.5 ug/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: AGTRSSRART TDARGCRLRS QLVPVSALGL GHSSDELIRF RFCSGSCRRA RSQHDLSLAS LLGAGALRSP PGSRPISQPC CRPTRYEAVS FMDVNSTWRT VDHLSATACG CLG
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 97% by SDS-PAGE gel and HPLC analyses.