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Gibco™ Mouse Artemin Recombinant Protein, PeproTech®

Catalog No. 45058250UG
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Catalog No. Quantity
45058250UG 250 μg
45058100UG 100 μg
450-58-1MG 1 mg
450-58-20UG 20 μg
45058500UG 500 μg
450-58-5UG 5 μg
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Catalog No. 45058250UG Supplier Gibco™ Supplier No. 45058250UG
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Description

Recombinant Protein

Recombinant Murine Artemin is a disulfide-linked homodimer formed by two identical 113 amino acid subunits with a calculated molecular weight of 24.2 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9Z0L2
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 11876
Molecular Weight (g/mol) 12.1 kDa
Name Mouse Artemin
Quantity 250 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias Artemin; ARTN; Enovin; EVN; NBN; neublastin; neurotrophic factor
Common Name Artemin
Gene Symbol ARTN
Biological Activity Determined by the dose-dependent stimulation of the proliferation of SH-SY5Y cells. The expected ED50 for this effect is 0.1-0.5 ug/ml
Conjugate Unconjugated
Recombinant Recombinant
Sequence AGTRSSRART TDARGCRLRS QLVPVSALGL GHSSDELIRF RFCSGSCRRA RSQHDLSLAS LLGAGALRSP PGSRPISQPC CRPTRYEAVS FMDVNSTWRT VDHLSATACG CLG
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 97% by SDS-PAGE gel and HPLC analyses.
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