Gibco™ Mouse Cardiotrophin-1 Recombinant Protein, PeproTech®

Catalog No.	Quantity
25025500UG	500 μg
25025100UG	100 μg
250-25-10UG	10 μg
250-25-1MG	1 mg
25025250UG	250 μg
250-25-2UG	2 μg
250-25-50UG	50 μg

Catalog No. 25025500UG Supplier Gibco™ Supplier No. 25025500UG

Description

Recombinant Protein

Recombinant Murine Cardiotrophin-1 is a 21.3 kDa protein consisting of 202 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Cardiotrophin-1 (CT-1) is a member of the IL-6 family of cytokines, which signal through gp130 receptor complexes. gp130 complexes with several different receptor subunits to transmit signals from Cardiotrophin-1, IL-6, LIF, OSM, CNTF and IL-11. Cardiotrophin-1 binds to and activates the leukemia inhibitory factor (LIF) receptor/gp130 receptor complex and has been shown to induce hypertrophy in cardiac myocytes in vitro. Cardiotrophin-1, a secreted protein expressed at high levels in myocardium during cardiogenesis, has been shown to promote proliferation and survival of embryonic cardiomyocytes, suggesting a role for Cardiotrophin-1 in the activation of gp130 during cardiac development.

Specifications

• Accession Number: Q60753
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 13019
• Molecular Weight (g/mol): 21.3 kDa
• Name: Mouse Cardiotrophin-1
• Quantity: 500 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: cardiophin 1; Cardiotrophin; cardiotrophin 1; Cardiotrophin1; cardiotrophin-1; CT 1; CT1; CT-1; CT-1 CT1; CTF 1; Ctf1; IL-6 cytokine family
• Common Name: Cardiotrophin 1
• Gene Symbol: CTF1
• Biological Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: SQREGSLEDH QTDSSISFLP HLEAKIRQTH NLARLLTKYA EQLLEEYVQQ QGEPFGLPGF SPPRLPLAGL SGPAPSHAGL PVSERLRQDA AALSVLPALL DAVRRRQAEL NPRAPRLLRS LEDAARQVRA LGAAVETVLA ALGAAARGPG PEPVTVATLF TANSTAGIFS AKVLGFHVCG LYGEWVSRTE GDLGQLVPGG VA
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.