Gibco™ Mouse CCL21 (6Ckine) Recombinant Protein

Catalog No.	Quantity
PMC1474	20 μg

Catalog No. PMC1474 Supplier Gibco™ Supplier No. PMC1474

Description

Recombinant Protein

Carrier-Free Reconstitution: We recommend that the vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute this protein in sterile, distilled water to a concentration of 0.1-1.0 mg/mL. Do not vortex. Further dilutions should be made in aqueous buffers supplemented with carrier protein, such as 0.1-1.0% BSA. Storage: This lyophilized preparation is stable at room temperature for 1 month, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2°C to 8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -80°C for 3months. Avoid repeated freeze/thaw cycles.

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

Specifications

• Accession Number: P84444, P86792, P86793
• For Use With (Application): Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 100042493, 18829, 65956
• Molecular Weight (g/mol): 12 kDa
• Name: Mouse CCL21 (6Ckine)
• Purification Method: Purified
• Quantity: 20 μg
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <0.1 ng/μg
• Gene Alias: 6 Ckine; 6CKBAC1; 6CKBAC2; 6Ckine; AI159701; ALP; AW987545; beta chemokine exodus-2; beta-chemokine exodus-2; CC chemokine 6Ckine-ser; C-C motif chemokine 21; C-C motif chemokine 21a; C-C motif chemokine 21b; C-C motif chemokine 21c; C-C motif chemokine ligand 21; CCL21; Ccl21a; Ccl21b; Ccl21c; Ccl21-leu; CCL21-Ser; chemokine (C-C motif) ligand 21; chemokine (C-C motif) ligand 21A (serine); chemokine (C-C motif) ligand 21B (leucine); chemokine (C-C motif) ligand 21b (serine); chemokine (C-C motif) ligand 21C (leucine); chemokine CCL21/6CKINE; CKb9; ECL; Efficient Chemoattractant for Lymphocytes; exodus-2; plt; Scya21; SCYA21a; Scya21b; Scya21c; secondary lymphoid organ chemokine; secondary lymphoid tissue chemokine; Secondary lymphoid-tissue chemokine; SLC; small inducible cytokine A21; small inducible cytokine A21a; small inducible cytokine A21c; small inducible cytokine subfamily A (Cys-Cys), member 21; small-inducible cytokine A21; Small-inducible cytokine A21a; Small-inducible cytokine A21b; Small-inducible cytokine A21c; TCA4; Thymus-derived chemotactic agent 4; UNQ784/PRO1600
• Common Name: CCL21
• Gene Symbol: Ccl21a, Ccl21b, Ccl21c
• Biological Activity: ED50 = 10 - 100 ng/mL; determined by the dose-dependent chemotaxis of human activated T-cells in the presence of IL-2.
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Mouse
• Recombinant: Recombinant
• Sequence: Mouse CCL21 recombinant protein contains 110 amino acids
• Content And Storage: -20°C
• Classification: Carrier-Free
• Activity: ED50 = 10 - 100 ng/mL; determined by the dose-dependent chemotaxis of human activated T-cells in the presence of IL-2.
• Endotoxin Level: <0.1 ng/μg
• Shipping Condition: Approved for shipment on Wet or Dry Ice
• Expression System: E. coli
• Protein Family: Chemokines & Receptors
• Protein Form: Recombinant, Ligand
• Form: Lyophilized
• Protein Subtype: 6 CKINE
• Research Category: Immunology
• Product Line: Gibco
• Purity or Quality Grade: ≥98% by SDS-PAGE and HPLC