Gibco™ Mouse CXCL12 (SDF-1a) Recombinant Protein

Catalog No.	Quantity
PMC1354	10 μg

Catalog No. PMC1354 Supplier Gibco™ Supplier No. PMC1354

Description

Recombinant Protein

Reconstitution: We recommend that the vial be briefly centrifuged prior to opening to bring the contents to the bottom. This lyophilized protein should be reconstituted in sterile distilled water to a concentration of 0.1-1.0 mg/mL. Further dilutions should be made in tissue culture grade buffered solutions with heat inactivated fetal calf serum or low endotoxin BSA. Storage: Lyophilized human SDF-1 alpha should be stored at 2°C to 8°C, preferably desiccated. Store reconstituted human SDF-1 alpha at < -20°C (not in a frost-free freezer). Keep freeze-thaw cycles to a minimum.

CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Accession Number: P40224
• For Use With (Application): Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 20315
• Molecular Weight (g/mol): 7.9 kDa
• Name: Mouse CXCL12 (SDF-1a)
• Purification Method: Purified
• Quantity: 10 μg
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <0.1 ng/μg
• Gene Alias: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; AI174028; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); CXC; CXC motif chemokine; C-X-C motif chemokine 12; C-X-C motif chemokine ligand 12; CXCL; Cxcl12; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF; pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; Scyb12; Sdf1; SDF-1; SDF-1 gamma; SDF1A; SDF-1a; SDF-1-alpha(3-67); SDF1B; SDF-1b; SDF-1-beta(3-72); Stromal cell-derived factor 1; stromal cell-derived factor-1 alpha; stromal cell-derived factor-1 gamma; thymic lymphoma cell-stimulating factor; TLSF; Tlsfa; TLSF-a; Tlsfb; TLSF-b; Tpar1
• Common Name: CXCL12
• Gene Symbol: CXCL12
• Biological Activity: ED50 = 50 - 100 ng/mL; determined by the dose-dependent chemotaxis of human PBMCs.
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Mouse
• Recombinant: Recombinant
• Sequence: KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK
• Content And Storage: -20°C
• Activity: ED50 = 50 - 100 ng/mL; determined by the dose-dependent chemotaxis of human PBMCs.
• Endotoxin Level: <0.1 ng/μg
• Shipping Condition: Approved for shipment on Wet or Dry Ice
• Expression System: E. coli
• Protein Family: Chemokines & Receptors
• Protein Form: Recombinant, Ligand
• Form: Lyophilized
• Protein Subtype: SDFs (Stromal Cell-Derived Factors)
• Research Category: Immunology, Stem Cell Research, Cardiovascular Research, Neurobiology
• Product Line: Gibco
• Purity or Quality Grade: >98% by SDS-PAGE