Invitrogen™ Mouse IFN-gamma Recombinant Protein

Catalog No.	Quantity
PIRP8617	100 μg

Catalog No. PIRP8617 Supplier Invitrogen™ Supplier No. RP8617

Description

Recombinant Protein

Interferon gamma (mouse) Recombinant Protein, RP-8617, from Invitrogen.

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia. RP-8617 contains 100μg of Interferon gamma (mouse) protein. RP-8617 may be used as a control for a variety of immunological studies. The RP-8617 molecular weight is ∽15.6 kDa. Reconstitute with sterile water to a concentration of 0.1mg/mL. It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage.

Specifications

• Accession Number: P01580
• Concentration: 0.1mg/mL
• For Use With (Application): Control
• Formulation: 10mM sodium phosphate with 50mM NaCl and no preservative; pH 7.5
• Gene ID (Entrez): 15978
• Molecular Weight (g/mol): ∽15.6
• Name: Mouse IFN gamma
• pH Range: 7.5
• Quantity: 100 μg
• Source: E. coli
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: M-IFN-g
• Common Name: Mouse IFN gamma
• Gene Symbol: Ifng
• Specific Reactivity: Mouse
• Conjugate: Unconjugated
• Cross Reactivity: Ms
• Species: E. coli
• Recombinant: Recombinant
• Form: Lyophilized
• Protein Subtype: Recombinant
• Purity or Quality Grade: purified

in vitro research only