Gibco™ Mouse IL-28A (IFN-lambda 2) Recombinant Protein, PeproTech®

Catalog No.	Quantity
25033100UG	100 μg
250-33-1MG	1 mg
250-33-20UG	20 μg
25033250UG	250 μg
25033500UG	500 μg
250-33-5UG	5 μg

Catalog No. 25033100UG Supplier Gibco™ Supplier No. 25033100UG

Description

Recombinant Protein

Recombinant Murine IFN- lambda2 is a 19.8 kDa protein containing 175 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IL-28A belongs to the IFN lambda family, a novel family of cytokines within the IL-10 superfamily. The three members of this family are IL-29 (IFN lambda 1), IL-28A (IFN lambda 2), and IL-28B (IFN lambda 3), and are also known as the type III Interferons.The IFN lambdas signal through a heterodimeric receptor of which one subunit, IL-10R2, is shared with other members of the superfamily. The second subunit, IFN lambda R1 or IL-28R alpha, is unique to the IFN lambdas. Signaling occurs through the Jak/STAT pathway in a similar manner as the type I IFN (IFN alpha/beta) and activates many of the same genes despite low sequence homology between the cytokines and receptors in the two families. Both IFN families display antiviral activity through the induction of antiviral protein production in target cells and the upregulation of MHC class I expression. These proteins also exhibit antiproliferative and antitumor effects, making them a possible alternative to IFN alpha cancer therapies. Unlike the type I IFN, which are able to stimulate most cells, response to IFN lambda stimulation appears to be limited to dendritic and some tumor cells due to the limited expression of IFN lambda R1. Another notable difference is the ability of the IFN lambda stimulation to drive dendritic cells towards the production of CD4+CD25+FoxP3+ regulatory T cells, suggesting a possible immunoregulatory role

Specifications

• Accession Number: Q4VK74
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 330496
• Molecular Weight (g/mol): 19.8 kDa
• Name: Mouse IL-28 A (IFN-lambda 2)
• Quantity: 100 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: cytokine Zcyto20; EG330496; Ifnl2; IFN-lambda2; IFN-lambda-2; Il28a; IL-28 A; ILN; interferon lambda 2; interferon lambda-2; interferon, lambda 2; interferon-lambda 2; interferon-lambda2; Interleukin; interleukin 28 A; interleukin 28 A (interferon, lambda 2); interleukin-28 A; ZCYTO20
• Common Name: IL-28 A
• Gene Symbol: IFNL2
• Biological Activity: Determined by its ability to activate STAT following receptor-ligand interaction.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKAKDAI EKRLLEKDMR CSSHLISRAW DLKQLQVQER PKALQAEVAL TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHRLQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.