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Gibco™ Mouse Neuropoietin Recombinant Protein, PeproTech®

Catalog No. 25025B25UG
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Catalog No. Quantity
25025B25UG 25 μg
25025B100UG 100 μg
250-25B-1MG 1 mg
25025B250UG 250 μg
25025B500UG 500 μg
250-25B-5UG 5 μg
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Catalog No. 25025B25UG Supplier Gibco™ Supplier No. 25025B25UG
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Description

Recombinant Protein

Recombinant Murine Neuropoietin is a 19.8 kDa protein containing 183 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex formed of a CNTF receptor-alpha component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons, and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human neuropoietin gene has evolved toward a pseudogene, suggesting that alternative signaling via CNTF is an effective compensatory pathway.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P83714
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 244218
Molecular Weight (g/mol) 19.8 kDa
Name Mouse Neuropoietin
Quantity 25 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias cardiotrophin 2; cardiotrophin-2; CT-2; Ctf2; CTF2P; Gm494; Neuropoietin; Np
Common Name Neuropoietin
Gene Symbol Ctf2
Biological Activity The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 0.5-0.8 ug/ml
Conjugate Unconjugated
Recombinant Recombinant
Sequence MAPISPSEPI GQAYSLALYM QKNTSALLQT YLQHQGSPFS DPGFSAPELQ LSTLPSAAVS FKTWHAMEDA ERLSRAQGAF LALTQHLQLV GDDQSYLNPG SPILLAQLGA ARLRAQGLLG NMAAIMTALG LPIPPEEDTL GFVPFGASAF ERKCRGYIVT REYGHWTDRA VRDLALLKAK YSA
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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