Invitrogen™ Mouse PD-1 His-tag Recombinant Protein

Catalog No.	Quantity
PIRP88248	1 mg
PIRP88247	100 μg

Catalog No. PIRP88248 Supplier Invitrogen™ Supplier No. RP88248

Description

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (840 μL) be added to the vial to prepare a stock solution of 1.19 mg/mL. Concentration is measured by UV.

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of 'danger signals' such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Specifications

• Accession Number: Q02242
• Concentration: 0.25 mg/mL
• For Use With (Application): Control, ELISA Standard, Binding Assay
• Format: Lyophilized
• Formulation: PBS with 5% mannitol, 5% trehalose and no preservative; pH 7.4
• Gene ID (Entrez): 18566
• Molecular Weight (g/mol): 40-45 kDa
• Name: Mouse PD-1 His-tag
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 1 mg
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Endotoxin Concentration: <1.0 EU/μg
• Gene Alias: CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
• Common Name: PD-1 (CD279)
• Gene Symbol: Pdcd1
• Biological Activity: Measured by its ability to bind PD-L1 Protein, Mouse, Recombinant (ECD, hFc Tag) in a functional ELISA.
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Mouse PD-1, amino acids Met1-Gln167 (Accession # NP_032824.1) with a C-terminal His-tag
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Activity: Measured by its ability to bind PD-L1 Protein, Mouse, Recombinant (ECD, hFc Tag) in a functional ELISA.
• Expression System: HEK293 cells
• Form: Lyophilized
• Purity or Quality Grade: ≥95% as determined by SDS-PAGE.