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R&D Systems™ Mouse Wnt-3a and Inhibitor IWR Set Protein

Catalog No. PSM1324
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PSM1324 1 Set
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Description

Extensive quality control produces industry leading bioactivity and lot-to-lot consistency that instills confidence in results and ensures reproducibility.

The Mouse Wnt-3a and Inhibitor IWR Set Protein is derived from CHO. The Mouse Wnt-3a and Inhibitor IWR Set Protein has been validated for the following applications: Bioactivity.

Specifications

For Use With (Application) Bioactivity
Gene ID (Entrez) 89780
Quantity 1 Set
Source Chinese Hamster Ovary cell line,CHO-derived mouse Wnt-3a protein
Storage Requirements Store the unopened product at -20 to -70° C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Gene Alias MGC119418, MGC119419, MGC119420, protein Wnt-3a, wingless-type MMTV integration site family, member 3A, Wnt3a
Common Name Wnt-3a
Gene Symbol Wnt3a
Biological Activity Recombinant Mouse Wnt-3a induces beta-catenin responsive Topflash activation in HEK293T cells. The specific Wnt pathway inhibitor, endo-IWR 1, inhibits Topflash activity from a 500ng/mL dose of Recombinant Mouse Wnt-3a with a typical ED50 < 0.2μM. The less active diasteriomer exo-IWR 1 Wnt inhibitor shows minor inhibitory activity in this assay.Recombinant Mouse Wnt-3a induces alkaline phosphatase production in the MC3T3-E1 mouse pre-osteoblast cell line. The ED50 for this effect is typically ≤ 5ng/mL. The specific Wnt pathway inhibitor, endo-IWR 1, inhibits alkaline phosphatase production induced from a 10ng/mL dose of Recombinant Mouse Wnt-3a with a typical ED50 < 0.8μM. The less active diasteriomer exo-IWR 1 Wnt inhibitor shows a > 5μM ED50 with a Recombinant Mouse Wnt-3a dose of 10ng/mL.
Conjugate Unconjugated
Species Mouse
Recombinant Recombinant
Expression System Chinese Hamster Ovary cell line, CHO-derived
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