Invitrogen™ MOV10L1 Polyclonal Antibody

Catalog No.	Quantity
PIPA598898	100 μg

Catalog No. PIPA598898 Supplier Invitrogen™ Supplier No. PA598898

Description

Rabbit Polyclonal Antibody

MOV10L1 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P), ELISA

Isoform 1: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Involved in the primary piRNA metabolic process (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). {ECO:0000269; PubMed:20534472, ECO:0000269; PubMed:20547853, ECO:0000269; PubMed:23166510, ECO:0000269; PubMed:25762440}.; Isoform 2: May act downstream of MEF2C during heart formation. Acts as a cardiac-specific suppressor of cardiomyocyte hypertrophy and cell cycle progression, suggesting that it may suppress these processes through the regulation of CDKN1A. Such results however require additional evidence. {ECO:0000305; PubMed:11854500}.

Specifications

• Antigen: MOV10L1
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 4.06 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene: MOV10L1
• Gene Accession No.: Q9BXT6
• Gene Alias: Cardiac helicase activated by MEF2 protein; cardiac helicase activated by MEF2C protein; cardiac-specific RNA helicase; Champ; Csm; DJ402G11.8; Moloney leukemia virus 10-like 1; moloney leukemia virus 10-like protein 1; Moloney leukemia virus 10-like protein 1 homolog; Mov10 RISC complex RNA helicase like 1; Mov10l1; Mov10l1, Moloney leukemia virus 10-like 1, homolog; Mov10-like 1; MOV10-like protein 1; MOV10-like protein 1 homolog; putative helicase Mov10l1; RNA helicase Mov10l1
• Gene Symbols: MOV10L1
• Host Species: Rabbit
• Immunogen: Recombinant Human RNA helicase Mov10l1 protein (336-425AA).
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 54456
• Target Species: Human
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG