Thermo Scientific Chemicals Moxifloxacin hydrochloride

Description

Moxifloxacin hydrochloride, CAS # 186826-86-8, is a broad-spectrum compound with antibacterial activity against both gram-positive and gram-negative bacteria. It also shows inhibitory activity against topoisomerase II.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Moxifloxacin hydrochloride is a fourth-generation synthetic fluoroquinolone compound with antibacterial activity against both gram-positive and gram-negative bacteria

• It also shows an inhibitory activity against topoisomerase II

• Moxifloxacin hydrochloride can bind to and inhibit both bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, resulting in DNA replication and repair inhibition thus induce cell death in sensitive bacterial species

• Moxifloxacin has 100 times higher affinity for bacterial DNA gyrase compared to mammalian DNA gyrase

Applications

• Moxifloxacin hydrochloride presents a higher anti-gram-positive activity compared to other fluoroquinolone such as ciprofloxacin and ofloxacin

• It has immunosuppressive activity that inhibits the proliferation of all classes of lymphocytes, which can induce apoptosis of antigen-presenting T cells

• It is a cytostatic anthracenedione that can intercalate DNA, increasing the occurence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA

• This compound shows anticancer activity in some animal models presenting leukemia

• Moxifloxacin is being investigated for the treatment of multidrug-resistant tuberculosis strains

Specifications

Chemical Identifiers

• CAS: 186826-86-8
• Molecular Formula: C21H25ClFN3O4
• Molecular Weight (g/mol): 437.896
• InChI Key: IDIIJJHBXUESQI-DFIJPDEKSA-N
• PubChem CID: 101526
• ChEBI: CHEBI:7008
• IUPAC Name: 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid;hydrochloride
• SMILES: COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O.Cl

• Type: Moxifloxacin Hydrochloride
• Melting Point: 324.0°C to 325.0°C
• Infrared Spectrum: Authentic
• Water: 5% max.
• Quantity: 1 g
• Formula Weight: 437.89
• Percent Purity: ≥97.5% (HPLC)
• Chemical Name or Material: Moxifloxacin hydrochloride

Safety and Handling

Hazard Category	Warning
Hazard Statement	GHS H Statement Harmful if swallowed. Causes serious eye irritation. Harmful to aquatic life with long lasting effects.
Precautionary Statement	GHS P Statement Wash face, hands and any exposed skin thoroughly after handling. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Avoid release to the environment. Dispose of contents/container to an approved waste disposal plant.

SDS

RUO – Research Use Only