Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Thermo Scientific Chemicals Moxifloxacin hydrochloride

Catalog No. AC457960010
Click to view available options
Quantity:
1 g

Moxifloxacin hydrochloride, CAS # 186826-86-8, is a broad-spectrum compound with antibacterial activity against both gram-positive and gram-negative bacteria. It also shows inhibitory activity against topoisomerase II.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Moxifloxacin hydrochloride is a fourth-generation synthetic fluoroquinolone compound with antibacterial activity against both gram-positive and gram-negative bacteria

• It also shows an inhibitory activity against topoisomerase II

• Moxifloxacin hydrochloride can bind to and inhibit both bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, resulting in DNA replication and repair inhibition thus induce cell death in sensitive bacterial species

• Moxifloxacin has 100 times higher affinity for bacterial DNA gyrase compared to mammalian DNA gyrase

Applications

• Moxifloxacin hydrochloride presents a higher anti-gram-positive activity compared to other fluoroquinolone such as ciprofloxacin and ofloxacin

• It has immunosuppressive activity that inhibits the proliferation of all classes of lymphocytes, which can induce apoptosis of antigen-presenting T cells

• It is a cytostatic anthracenedione that can intercalate DNA, increasing the occurence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA

• This compound shows anticancer activity in some animal models presenting leukemia

• Moxifloxacin is being investigated for the treatment of multidrug-resistant tuberculosis strains

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 186826-86-8
Molecular Formula C21H25ClFN3O4
Molecular Weight (g/mol) 437.896
InChI Key IDIIJJHBXUESQI-DFIJPDEKSA-N
PubChem CID 101526
ChEBI CHEBI:7008
IUPAC Name 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid;hydrochloride
SMILES COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O.Cl

Specifications

Type Moxifloxacin Hydrochloride
Melting Point 324.0°C to 325.0°C
Infrared Spectrum Authentic
Water 5% max.
Quantity 1 g
Formula Weight 437.89
Percent Purity ≥97.5% (HPLC)
Chemical Name or Material Moxifloxacin hydrochloride
Hazard Category Warning
Hazard Statement GHS H Statement Harmful if swallowed. Causes serious eye irritation. Harmful to aquatic life with long lasting effects.
Precautionary Statement GHS P Statement Wash face, hands and any exposed skin thoroughly after handling. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Avoid release to the environment. Dispose of contents/container to an approved waste disposal plant.

RUO – Research Use Only

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.