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Tocris Bioscience™ MP A08

Catalog No. 580350
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50 mg
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Catalog No.
58-035-0 50 mg
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Catalog No. 58-035-0 Supplier Tocris Bioscience™ Supplier No. 5803/50
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Description

Selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor

MP A08 is a selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.

Specifications

Chemical Name or Material 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
CAS 219832-49-2
Synonym NSC 122314
Quantity 50 mg
Molecular Formula C27H25N3O4S2
Formula Weight 519.64
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