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MP Biomedicals™ Hyaluronidase, Streptomyces hyalurolyticus
Description
Hyaluronidase is the enzyme that degrades hyaluronic acid in mucopolysaccharides to low molecular saccharides. Hyaluronidase purified from Streptomyeshyalurolyticus is distinct from the known hyaluronidase in its substrate specificity and mechanism of action. This enzyme is quite specific for hyaluronic acid. Various types of chondroitin sulfate (A,B,C,D,,E), chondroitin, heparin, keratan sulfate and chitin are not attacked by this enzyme. This enzyme splits the N-acetylglucosaminic linkages in hyaluronic acid eliminatively , yielding ▿-4,5-unsaturated tetrasaccharides and hexasaccharides as the end-product.
- Formula Weight: 55kDa
- CAS #: 37326-33-3
- Synonyms: EC 4.2.2.1; Hyaluronate lyase; Mucinase
- Physical Appearance : White lyophilized powder
- Typical : ã 2,000 TRU/mg protein
- Contaminants : Protease activity: less than 0.05 u/ampule. One unit is the amount of protease activity which produces 100 ++g of tyrosine from milk casein at 37°C for 60 min. (pH 6.0)
- Optimum pH: 6.0
- Recommended reaction temperature : 60°C
- Molecular Weight : 91,000 (gel filtration)
- Inhibitors : Mn2+, Hg2+, Potassium ferricyanide
- Unit Definition : One TRU (Turbidity Reducing Unit) is that amount of enzyme which causes 50% of decrease in absorbance at 660 nm in 30 minutes at 60°C.
Specifications
Specifications
| Concentration | ≈2000 U/mg |
| Color | White |
| pH | 6 |
| For Use With (Application) | Used to increase the absorption and dispersion of injected drugs or to disrupt the structure of certain organs |
| Content And Storage | 4°C |
| Source | Streptomyces hyalurolyticus |
| Quantity | 400 U |
| Product Type | Hyaluronidase |
| Molecular Weight (g/mol) | 91000 |
| Inhibitors | Mn2+, Hg2+, Potassium Ferricyanide |
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Safety and Handling
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