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Tocris Bioscience™ MPEP hydrochloride
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Catalog No. 121210
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12-121-0 10 mg
12-125-0R 50 mg
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Description

Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors

MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

Specifications

Chemical Name or Material 2-Methyl-6-(phenylethynyl)pyridine hydrochloride
CAS 219911-35-0
Assay Percent Range >99%
Quantity 10 mg
Solubility Soluble to 100mM in DMSO
Target Group I mGluR Antagonists
Molecular Formula C14H11N.HCl
Formula Weight Observed MW: 229.71
Purity 99%

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