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MPZ/P0 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. p-7088088 Shop All Proteintech Group Inc Products
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50-172-6416 150 μL
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Catalog No. 50-172-6416 Supplier Proteintech Group Inc Supplier No. 105721AP150UL
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Description

Rabbit Polyclonal Antibody

This antibody can recognize endogenous MPZ, and can be used as a marker of myelinating Schwann cells.

Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e. g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

Specifications

Antigen MPZ/P0
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Concentration 0.19 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene MPZ
Gene Accession No. P06907, P25189, P27573
Gene Alias CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, DSS, HMSNIB, MPP, MPZ, Myelin peripheral protein, Myelin protein P0, myelin protein zero, P0
Gene Symbols Mpz
Host Species Rabbit
Immunogen MPZ,P0 Fusion Protein Ag0848
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17528, 24564, 4359
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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