MPZ/P0 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-6416	Proteintech Group Inc 105721AP150UL	150 μL

Description

This antibody can recognize endogenous MPZ, and can be used as a marker of myelinating Schwann cells.

Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e. g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

Specifications

• Antigen: MPZ/P0
• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P06907, P25189, P27573
• Gene ID (Entrez): 17528, 24564, 4359
• Immunogen: MPZ,P0 Fusion Protein Ag0848
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MPZ

• Concentration: 0.19 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, DSS, HMSNIB, MPP, MPZ, Myelin peripheral protein, Myelin protein P0, myelin protein zero, P0
• Gene Symbols: Mpz
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody