Invitrogen™ MRCK alpha Polyclonal Antibody

Catalog No.	Quantity
PIPA584863	100 μL

Catalog No. PIPA584863 Supplier Invitrogen™ Supplier No. PA584863

Description

Rabbit Polyclonal Antibody

Immunogen sequence: TRRESQSERE EFESEFKQQY EREKVLLTEE NKKLTSELDK LTTLYENLSI HNQQLEEEVK D Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 90%.

CDC42BPA (MRCKA) is a serine/threonine kinase which functions in actin cytoskeleton assembly and organization. Three independent coiled-coil domains and the N-terminal region preceding the kinase domain are responsible for intermolecular interactions leading to MRCK alpha multimerization. The transautophosphorylation process is critical for regulation of MRCK alpha catalytic activities. Binding of phorbol esters to MRCK releases its autoinhibition, allowing N-terminal dimerization and subsequent kinase activation.

Specifications

• Antigen: MRCK alpha
• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry, Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.4 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: CDC42BPA
• Gene Accession No.: Q5VT25
• Gene Alias: A930014J19Rik; CDC42 binding protein kinase alpha; CDC42 binding protein kinase alpha (DMPK-like); CDC42 binidng protein kinase beta; CDC42-binding protein kinase alpha; CDC42-binding protein kinase alpha (DMPK-like); CDC42BPA; cdc42bpa {ECO:0000250; DKFZp686L1738; DKFZp686P1738; DMPK-like; DMPK-like alpha; FLJ23347; Kiaa0451; MRCK; MRCK alpha; MRCKA; myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy kinase-related CDC-42-binding kinase-alpha; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; myotonic dystrophy protein kinase-like alpha; mytonic dystrophy kinase-related Cdc42-binding kinase; PK428; RP5-1087E8.4; serine/threonine-protein kinase MRCK alpha; ser-thr protein kinase PK428; ser-thr protein kinase related to the myotonic dystrophy protein kinase; UniProtKB:Q5VT25}
• Gene Symbols: CDC42BPA
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human CDC42BPA. Recombinant protein control fragment (Product #RP-107808).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8476
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG