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MRGPRX2 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA532931
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PIPA532931 50 μg
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Catalog No. PIPA532931 Supplier Thermo Scientific Supplier No. PA532931

Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human (100%); Chimpanzee, Gorilla, Monkey (94%); Orangutan (88%); Gibbon (81%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MRGPRX2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene MRGPRX2
Gene Accession No. Q96LB1
Gene Alias G protein-coupled receptor MRGX2; G370024M05Rik; MAS related GPR family member X2; Mas-related G protein-coupled receptor G3; MAS-related GPR, member B10; MAS-related GPR, member X2; mas-related G-protein coupled receptor member B10; Mas-related G-protein coupled receptor member X2; MGRG3; MrgB10; Mrgprb10; Mrgprx2; MRGX2
Gene Symbols MRGPRX2
Host Species Rabbit
Immunogen Synthetic 16 amino acid peptide from 3rd extracellular domain of human MRGPRX2 / MRGX2.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117194
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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