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Invitrogen™ MRP2 Monoclonal Antibody (M2I-4)
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Catalog No. 01671041
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01-671-041 1 mL
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Catalog No. 01-671-041 Supplier Invitrogen™ Supplier No. MA135603
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Description

Mouse Monoclonal Antibody

M2I-4 reacts with an internal epitope of cMOAT/MRP2, a 170-180 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2I-4 was raised against a bacterial fusion protein of cMOAB/MRP2, containing amino acids 215-310 of the protein. M2I-4 did not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products.

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.
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Specifications

Antigen MRP2
Applications Flow Cytometry, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone M2I-4
Concentration 250 μg/mL
Conjugate Unconjugated
Formulation Tissue culture supernatant with 0.7% BSA and 0.1% sodium azide
Gene ABCC2
Gene Accession No. Q92887
Gene Alias ABC30; Abcc2; AI173996; ATP binding cassette subfamily C member 2; ATP-binding cassette sub-family C member 2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; calicular multispecific organic anion transporter; canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Cmoat; CMOAT1; Cmrp; DJS; Human MRP2; KIAA1010; MRP2; multidrug resistance associated protein 2; multidrug resistance protein 2; multidrug resistance-associated protein 2
Gene Symbols ABCC2
Host Species Mouse
Immunogen cMOAB/MRP2 amino acids 215-310.
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1244
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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