Invitrogen™ MRP3 Monoclonal Antibody (M3II-21)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA135679

Catalog No. 01-671-085

Description

The antibody reacts with an internal epitope of MRP3, a 190-200 kD transmembrane protein that is closely related to the multidrug resistance protein MRP1. M3II-21 was raised against a bacterial fusion protein of MRP3, containing amino acids 830-949 of the protein. M3II-21 does not cross-react with the human MDR1, MRP1, MRP2 or MRP5 gene products. M3II-21 has potential value for detection of MRP3-mediated drug-resistance in human tumor samples.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Specifications

• Antigen: MRP3
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Tissue culture supernatant with 0.7% BSA and 0.1% sodium azide
• Gene Accession No.: O15438
• Gene Symbols: ABCC3
• Immunogen: MRP3 aa 830-949.
• Regulatory Status: RUO
• Gene ID (Entrez): 8714
• Content And Storage: 2°C to 8°C
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Clone: M3II-21
• Conjugate: Unconjugated
• Gene: ABCC3
• Gene Alias: ABC31; ABCC3; ATP binding cassette subfamily C member 3; ATP-binding cassette sub-family C member 3; ATP-binding cassette, subfamily C (CFTR/MRP), member 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2; canicular multispecific organic anion transporter; cMOAT2; DKFZp686E22157; EST90757; MLP2; MLP-2; MOAT-D; Mrp3; MRP-like protein 2; multidrug resistance associated protein; multidrug resistance protein 3; multidrug resistance-associated protein 3; multi-specific organic anion transporter D; organic anion transporter
• Host Species: Mouse
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

Safety and Handling

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