Invitrogen™ MRP6 Monoclonal Antibody (M6II-7)

Catalog No.	Quantity
01-671-091	1 mL

Catalog No. 01-671-091 Supplier Invitrogen™ Supplier No. MA135685

Description

Rat Monoclonal Antibody

M6II-7 reacts with MRP6, a 190-200 kD transmembrane protein that is related to the multidrug resistance related protein MRP. Mutations in the MRP6 gene are responsible for the connective tissue disorder Pseudoxanthoma elasticum (PXE). M6II-7 was raised against a bacterial fusion protein of human MRP6, containing amino acids 764-964, spanning the putative 12th transmembrane region as well as predicted internal and external regions of the protein. M6II-7 did not cross-react with the human MDR1, MRP1, MRP2, MRP3, MRP4, MRP5 gene products. unreactive on standard IHC-P.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.

Specifications

• Antigen: MRP6
• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: M6II-7
• Concentration: 0.25 mg/mL
• Conjugate: Unconjugated
• Formulation: Tissue culture supernatant with 1% BSA and 0.1% sodium azide
• Gene: ABCC6
• Gene Accession No.: O95255
• Gene Alias: ABC34; Abcc1b; ABCC6; Anthracycline resistance-associated protein; ARA; ATP binding cassette subfamily C member 6; ATP-binding cassette sub-family C member 6; ATP-binding cassette, subfamily C (CFTR/MRP), member 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; ATP-binding cassette, sub-family C, member 6; DCC; dyscalc; Dyscalc1; EST349056; GACI2; liver multidrug resistance-associated protein 6; Mlp1; MLP-1; MOATE; MOAT-E; Mrp6; MRP-like protein 1; Multidrug resistance-associated protein 6; multidrug resistance-associated protein-6; multi-specific organic anion transporter E; PXE; PXE1; URG7; URG7 protein; multidrug resistance-associated protein 6
• Gene Symbols: ABCC6
• Host Species: Rat
• Immunogen: ABCC6 aa 764-964.
• Quantity: 1 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 368
• Target Species: Human
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a