Tocris™ MS 436

Potent and selective BRD4(1) inhibitor

Manufacturer: Tocris™ 5173/50

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Catalog No. 51-735-0

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    Inhibitors MS 436
    Purity >98
    Molecular Weight 383.42
    Quantity 50mg
    Product Type MS 436

    Potent and selective BRD4 bromodomain inhibitor (Ki = 30 - 50nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9µM, respectively). Attenuates melanoma cell proliferation in vitro.

    • Chemical Name: (E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
    • Formula: C18H17N5O3S
    • CAS Number: 1395084-25-9
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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