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  5. Tocris Bioscience™ MS 436

Tocris Bioscience™ MS 436

Catalog No. 517350
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Catalog No. Quantity
51-735-0 50 mg
51-731-0 10 mg
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Catalog No. 51-735-0 Supplier Tocris Bioscience™ Supplier No. 5173/50
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Description

Potent and selective BRD4(1) inhibitor

MS 436 is a potent and selective BRD4 bromodomain inhibitor (Ki = 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 μM, respectively). Attenuates melanoma cell proliferation in vitro.

Specifications

Purity >98%
Quantity 50 mg
Product Type MS 436
Molecular Weight (g/mol) 383.42
Inhibitors MS 436

For Research Use Only

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