MSH2 Mouse anti-Human, Clone: UMAB259, liquid, UltraMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene UM800149

Catalog No. 50-168-5423

Description

Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSbeta, which binds to insertion/deletion loops in DNA.

Specifications

• Antigen: MSH2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: MSH2
• Gene Alias: COCA1, FCC1, HNPCC, HNPCC1, LCFS2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4436
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Clone: UMAB259
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P43246
• Gene Symbols: MSH2
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-304 of human MSH2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b