MSH2 Mouse anti-Human, Clone: UMAB259, liquid, UltraMAB™

Catalog No.	Quantity
50-168-5423	100 μL

Catalog No. 50-168-5423 Supplier OriGene Supplier No. UM800149

Description

Mouse Monoclonal Antibody

Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSbeta, which binds to insertion/deletion loops in DNA.

Specifications

• Antigen: MSH2
• Applications: Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: UMAB259
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: MSH2
• Gene Accession No.: P43246
• Gene Alias: COCA1, FCC1, HNPCC, HNPCC1, LCFS2
• Gene Symbols: MSH2
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-304 of human MSH2 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4436
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b