Invitrogen™ MTA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA579699

Catalog No. PIPA579699

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human MCF-7 whole cell, human HEK293 whole cell, human HELA whole cell, human PC-3 whole cell, human Raji whole cell, human K562 whole cell, rat brain tissue, mouse brain tissue. IHC: Human Rectal Cancer Tissue, rat ovary tissue, rat ovary tissue, mouse brain tissue, human ovarian cancer tissue, human pancrease cancer tissue IHC-F: Rat Ovary Tissue, mouse brain tissue.

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

Specifications

• Antigen: MTA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MTA1
• Gene Alias: metastasis associated 1; metastasis associated gene 1 protein; metastasis-associated protein MTA1; MTA1; Zg29
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116870, 64520, 9112
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
• Gene Accession No.: Q13330, Q62599, Q8K4B0
• Gene Symbols: MTA1
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MTA1 (676-696aa ETKRAARRPYKPIALRQSQAL).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG