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MTA2 Mouse anti-Human, Mouse, Clone: 2G12G4, Proteintech
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Catalog No. 501736629 Shop All Proteintech Group Inc Products
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50-173-6629 150 μL
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Catalog No. 50-173-6629 Supplier Proteintech Group Inc Supplier No. 661951IG150UL
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Description

Mouse Monoclonal Antibody

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Specifications

Antigen MTA2
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2G12G4
Concentration 1.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MTA2
Gene Accession No. O94776, Q9R190
Gene Alias Metastasis associated 1 like 1, MTA1 L1 protein, MTA1L1, MTA2, PID
Gene Symbols MTA2
Host Species Mouse
Immunogen MTA2 Fusion Protein Ag11713
Purification Method Protein A
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23942, 9219
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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