MTA2 Mouse anti-Human, Mouse, Clone: 2G12G4, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 661951IG150UL

Catalog No. 50-173-6629

Description

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Specifications

• Antigen: MTA2
• Classification: Monoclonal
• Concentration: 1.4 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O94776, Q9R190
• Gene Symbols: MTA2
• Immunogen: MTA2 Fusion Protein Ag11713
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: 2G12G4
• Conjugate: Unconjugated
• Gene: MTA2
• Gene Alias: Metastasis associated 1 like 1, MTA1 L1 protein, MTA1L1, MTA2, PID
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 23942, 9219
• Content And Storage: -20°C
• Form: Liquid